Suzhou University, China
Posters & Accepted Abstracts: J Nutr Food Sci
A Poria cocos is a medicinal herb widely used in China both as medicine and food. Pachymaran, an active component of Poria cocos, when chemically modified to sulfated pachymaran (SP) exhibits enhanced water solubility and enhanced bioactivities with respect to antioxidant, antitumor and immune modulation activities. We have examined the possible protective effect of SP against Parkinson disease (PD). PD is a neurodegenerative disorder of the central nervous system (CNS) common to older people. In a cell culture model, we have observed protective effects of SP on MPP+ induced PC12 cell death. SP prevented apoptosis in MPP+ induced PC12 cells via inhibiting the activation of procaspase-3, down-regulation of Bcl-2 and up-regulation of Bax. Moreover, an in vivo PD mouse model was established for validating the PD treatment efficacy of SP. We found that treatment with SP attenuated the damage of dopaminergic neurons in the substantia nigra and striatal neurons induced by 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP). SP treatment reversed the changes in the number of tyrosine hydroxylase (TH) positive cells in substantia nigra and the changes of expression levels of Bcl-2, Bax in the midbrain and striatum when compared with MPTP-treated group. Hence, these studies provide evidence for the potential application of SP in the therapy of PD.
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