SVMS University of Nottingham, UK
Posters-Accepted Abstracts: J Nutr Food Sci
Neonatal and fetal death is increased if the fetus is male. Physiological mechanisms that may affect this condition are a focus of this study. Evidence is emerging of a sex specific difference in fetal and placental perfusion. This study investigates the effects of dietary intervention at specific time points upon blood flow, placental development and fetal growth trajectory. Increased preconception dietary protein increased uterine artery pulsatility index and reduced TAMV (p=0.03). Blood flow volume was affected by sex being increased in those females carrying males (p=0.05). Affects upon fetal and placental growth were also sex specific with the male feto placental unit significantly affected by the preconception diet (p=>0.05). Interestingly, preconception diet retarded fetal growth at either the lowest (7% CP) or highest diet (18%CP) with no difference occurring between 10 or 14% CP. Only the 7% post-conception diet however reduced growth (p=0.009). Sex specific dietary effects upon fetal organ growth, in particular those associated with immune function, were found and associated with increased antimicrobial use in these male calves. In contrast, the cardiovascular system was more affected in the female fetus and weaner and by the post-conception diet.These results suggest preconception diet influences oocyte and embryo development which may have long term and sex specific effects for the offspring.
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