Obesity, insulin resistance and gene variation in multi-ethnic Malaysian adults
Journal of Nutrition & Food Sciences

Journal of Nutrition & Food Sciences
Open Access

ISSN: 2155-9600


Obesity, insulin resistance and gene variation in multi-ethnic Malaysian adults

9th International Congress on Nutrition & Health

February 20-21, 2017 Berlin, Germany

Mitra S R, Tan P Y and Farahnaz Amini

University of Nottingham, Malaysia
UCSI University, Malaysia

Posters & Accepted Abstracts: J Nutr Food Sci

Abstract :

In order to tackle obesity-related non-communicable diseases, we aimed to evaluate and explore interaction between anthropometric indices, blood biochemical parameters, dietary intake and selected gene polymorphisms in apparently healthy Malaysians of three ethnic groups. Malaysian adults (Malaysian Malays, Malaysian Chinese and Malaysian Indians) with BMI>23 from communities living in Selangor are our participants. Our results reveal, mean age (├?┬▒SD) is 43.0y (├?┬▒10.1) for women (n=93) and 41.0y (├?┬▒13.5) for male (n=20) participants. Average BMI on the combined data is 29.7kg/m2 (├?┬▒5.1), significantly higher (P=0.01) than 23 kg/m2 which is the current cut off for categorization as ├ó┬?┬?overweight├ó┬?┬? for South East Asian individuals. Mean fat mass for females is 33.9 kg (├?┬▒1.1) and for the male is 31.3 kg (├?┬▒17.6). Mean body fat percentage is 42.7% (├?┬▒5.3) for females (normal range: 18~28) and 34.2% (├?┬▒7.8) for the male (normal range: 10~20). Mean waist circumference is 92.1 cm (├?┬▒12.2) for females (normal: 80) and 106.5 cm (├?┬▒14.9) for the male (normal: 90). Indians have significantly lower HDL cholesterol (p=0.001), higher fasting insulin (p=0.002) and HOMA-IR (p=0.001) (1.3├?┬▒0.3 mmol/L, 14.3├?┬▒13.3 uU/ml and 1.8├?┬▒1.5) compared to Malays (1.7├?┬▒0.5 mmol/L, 7.0├?┬▒5.20 uU/ml and 0.9├?┬▒0.6) and Chinese (1.6├?┬▒0.4 mmol/L, 7.9├?┬▒5.2 uU/ml and 1.0├?┬▒0.6), respectively. There is ethnicity difference on the effect of FTO gene variants as below. Indians carrying GG genotype of FTO rs9930501 were compromised when compared to GA and AA genotypes respectively, with respect to fasting glucose (6.4├?┬▒2.2 mmol/L against 4.7├?┬▒0.1mmol/L and 5.0├?┬▒0.6mmol/L, p=0.016) and HOMA-IR (2.3├?┬▒1.6 against 2.0├?┬▒1.7 and 10├?┬▒0.5, p=0.018), BMI (34.6├?┬▒13.1 kg/m2 against 26.7├?┬▒3.6 kg/m2 and 28.8├?┬▒4.3 kg/m2, p=0.052) and body weight (97.6├?┬▒52.6 kg against 66.6├?┬▒10.0 kg and 76.6├?┬▒15.2 kg/m2, p=0.034). Whereas the Chinese carrying GA genotype were compromised with respect to body weight (72.1├?┬▒4.3 kg against 109.1 kg), BMI (27.8├?┬▒10.8 kg/m2 against 37.3 kg/m2), WC (82.9├?┬▒1.8 cm against 121.0 cm) and serum leptin level (7.0├?┬▒1.6 ng/ml against 17.8 ng/ml) when compared to AA genotype. A diet and exercise intervention is ongoing in the above population.

Biography :

Email: [email protected]