Xin Zhao, Rui Fang and Jianping Xiao
Nanjing Medical University, China
Posters & Accepted Abstracts: J Nutr Food Sci
The association between maternal vitamin D deficiency and risk of severe preeclampsia is still debated. In this study, we aimed to evaluate vitamin D status in Chinese pregnant women and determine its correlation with the odds of severe preeclampsia. We conducted a study on 13,806 pregnant women who routinely visited the antenatal care clinics and subsequently delivered at the Wuxi Maternity and Child Health Hospital (31.57�?°N). Of all the subjects, the majority (80.8%) in the cohort had their serum 25(OH) D levels assessed at 23-28 weeks of gestation. A high prevalence of maternal 25(OH) D<50 nmol/L was found (78.9%). The serum 25(OH) D levels among pregnant women with different pre-pregnancy BMI was significantly different implying that pre-pregnancy obesity might be a risk factor of maternal vitamin D deficiency. There was also a significant difference in the maternal 25(OH) D among different age groups. The serum 25(OH) D concentrations were significantly lower in pregnant women who subsequently developed severe preeclampsia compared with those who did not. Maternal 25(OH) D of <50 nmol/L at 23-28 weeks of gestation was strongly associated with an increased risk of severe preeclampsia after adjusting for potential confounders (adjusted odds ratio, 3.16; 95% CI, 1.77-5.65). Further research on the association of vitamin D status with related pregnancy outcomes is warranted.