Journal of Nutrition & Food Sciences
Open Access
ISSN: 2155-9600
ISSN: 2155-9600
Claudio Bernal, Paola Illesca and Marcela Gonz�lez
Poster Presentations: J Nutr Food Sci
Aim: evaluate the effects of isomeric fatty acids (FA): trans Fatty Acids (tFA) and Conjugated Linoleic Acid (CLA) on bile flow (BF), secretion of biliary acid (BA), lipids and proteins, as well as, FA composition of bile lipids in rats fed recommended- (RF) and high-fats (HF) diets. Materials & Methods: Male Wistar rats weighing 100 g were fed a RF (7%) or HF (20%) diets containing tFA, CLA or Linoleic Acid (LA) during 30 days. After bile-duct cannulation, bile was collected during 60 minutes, bile flow (BF) was estimated and BA, cholesterol, phospholipids and FA composition were determined by official methods. Conclusions: Isomeric FA: tFA and CLA increased the BF at HF diets by increase the BA content without changes in the cholesterol, phospholipids and protein content. Since 16:0 and 16:1 are decreased in liver and bile, an inhibition in lipogenesis and increased β-oxidation might be associated to a higher production of Acetyl CoA ?key substrate for the BA synthesis- and therefore a raised BF dependent of BA.
Claudio Bernal has completed his Ph.D from Universidad Nacional del Litoral (UNL) and postdoctoral studies from Clinical Nutrition Unit, Montefiore University Hospital, Pittsburgh, USA. He obtained many external positions as Visitant Professor. He is the director of Food Science and Nutrition Group (UNL) and Researcher of the National Council of Scientific and Technological Research. He is Chairman of Nutrition B.Sc. He has published more than 30 manuscripts, directed more than 20 professionals including doctoral thesis, post-doc fellows and research fellows. In addition, he directed many international and national research grants. He is an advisor of Food Companies.