Antioxidative and anti-adipogenesis activity of flavonoids
Journal of Nutrition & Food Sciences

Journal of Nutrition & Food Sciences
Open Access

ISSN: 2155-9600

Antioxidative and anti-adipogenesis activity of flavonoids

2nd International Conference on Nutraceuticals and Nutrition Supplements

July 18-19, 2016 Bangkok, Thailand

Narumol Krueyos and Wasaporn Chanput

Kasetsart University, Thailand

Posters & Accepted Abstracts: J Nutr Food Sci

Abstract :

Flavonoids are secondary metabolites produced from plants. Human obtain flavonoids through consumption of vegetables, fruits, tea and legumes. Health benefits of flavonoids, such as anti-oxidant, anti-bacteria, anti-hypertension and anti-adipogenesis are wildly known among researchers as well as consumers. Flavonoids are benzo-√?¬≥-pyrone derivatives consisting of phenolic and pyrane rings. There are five subclasses of flavonoids; flavonols, flavanols, anthocyanidins, flavones and flavanones, which differ in the arrangements of hydroxyl, methoxy and glycosidic side groups. In this study, we examined anti-oxidative and anti-adipogenesis activity of three groups of flavonoids: (1) Flavone: luteolin, apigenin (2) Flavonol: Quercetin, kampferol (3) Flavanone: Naringenin, eriodictyol. Antioxidative activity was performed using four assays; ABTS, DPPH, ORAC and xanthine oxidase. 3T3-L1 cell line was used to examine anti-adipogenesis. Different antioxidative trend was observed due to mechanisms of each method. Among six flavonoids, quercetin showed the lowest IC50. Anti-adipogenesis activity in which, lipid and triglyceride accumulation and expression of perroxisome proliferator-activated receptors gamma (PPAR√?¬≥) gene were investigated in the pre-adipocyte cell line. Correlation between antioxidative activity of flavonoids and anti-adipogenesis will be studied. Structure-function relationship of flavonoids in both antioxidative and anti-adipogenesis will be investigated.

Biography :

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