Journal of Nutrition & Food Sciences
Open Access
ISSN: 2155-9600
ISSN: 2155-9600
R&D Indena SpA, Viale Ortles 12-20139 Milan, Italy
Research Article
Targeting Cannabinoid Receptors and Fatty Acid Amide Hydrolase: An Innovative Food-Grade Delivery System of Zingiber officinale and Acmella oleracea Extracts as Natural Adjuvant in Pain Management
Author(s): Giovanna Petrangolini, Fabio Donzelli, Davide Berlanda, Pietro Allegrini, Andrea Rossignoli, Michela Stucchi and Antonella Riva*
Background: Anti-inflammatory and analgesic properties are displayed by several natural products, in particular
Acmella oleracea and Zingiber officinale. Literature data suggests that both botanical extracts can be useful as
inflammation/pain modulators, so technological efforts have been made to associate them together in a unique
delivery new food-grade formulation, Mitidol, with the purpose of improving their beneficial effects.
Objective: The aim of the present work was to assess if Mitidol and its active ingredients are able to modulate the
endocannabinoid 2 receptor system, one of the major systems responsible for positive effects of Cannabis treatment.
Cannabinoid 2 receptor represents an attractive pharmacological target in obtaining an anti-inflammatory/analgesic
effect with low central nervous sy.. View More»
DOI:
10.35248/2155-9600.20.10.1000766