Journal of Nutrition & Food Sciences
Open Access
ISSN: 2155-9600
ISSN: 2155-9600
Department of Cosmetic Science and Institute of Cosmetic Science, Chia Nan University of Pharmacy and Science, Tainan, Taiwan
Research Article
Evaluating Sialic Acid-Enhanced Skin Benefits of Ligilactobacillus salivarius (TCI153): A Randomized Double-Blind, Placebo-Controlled Trial
Author(s): Yung-Kai Lin, Chia-Hua Liang, Yung-Hsiang Lin, Shu-Ting Chan and Chi-Fu Chiang*
With aging, skin elasticity decreases, and fine lines emerge. Recently, sialic acid has gained attention for its role in boosting skin hydration, elasticity, and radiance. The “gut-skin axis” concept also underscores how probiotics can enhance skin beauty by modulating the gut microbiome, reducing inflammation, and supporting healthier skin. This study aimed to evaluate the effects of the probiotic Ligilactobacillus salivarius (TCI153) on skin health through both clinical and in vitro approaches. In human dermal fibroblasts, TCI153 significantly increased sialic acid production (~280 μg/mL), upregulated COL1A1 gene expression by 1.23-fold, enhanced elastin synthesis by 16%, and promoted collagen gel contraction by 5%, indicating potential benefits for skin firmness and extracellular matrix support. Clinically, sixty subjects were randomly.. View More»
DOI:
10.35248/2155-9600.25.15.80