Journal of Nutrition & Food Sciences
Open Access
ISSN: 2155-9600
ISSN: 2155-9600
Department of Bioresource Sciences, Nihon University, Kanagawa, Japan
Research Article
Anti-inflammatory Effect of Alpha-Lactalbumin on Lipopolysaccharide-stimulated RAW 264.7 Macrophages and Galactosamine/Lipopolysaccharide-Induced Liver Injury in Rats
Author(s): Akika Fukawa*, Orie Kobayashi, Makoto Yamaguchi and Akira Hosono
Objective: Alpha-lactalbumin (αLA) accounts for about 20% of whey protein, which shown to have anti-inflammatory effects, but its effects on acute hepatitis have not been reported. We investigated the hepatoprotective effects of αLA in an acute hepatitis model. Since the effects of αLA on macrophages, which are related to inflammation, have not been clarified, we conducted DNA microarrays to investigate the anti-inflammatory mechanism of αLA. Methods: Sprague-Dawley rats were divided into three groups; control diet-fed group (Normal), D-galactosamine (GalN) and lipopolysaccharide (LPS)-treated and control diet-fed group (GalN/LPS), and GalN/LPS-treated, αLA- containing diet-fed group (GalN/LPS+αLA). One week after starting the test diet, rats were injected with GalN/LPS and the parameters in blood and liver were eva.. View More»