Journal of Chromatography & Separation Techniques
Open Access
ISSN: 2157-7064
ISSN: 2157-7064
Yu-Sheng Lin
Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences,
Suzhou, Jiangsu, 215123
China
Research Article
Investigation of Cells Migration Effects in Microfluidic Chips
Author(s): Yu-Sheng Lin, Wenting Liu and Chunfei Hu
Yu-Sheng Lin, Wenting Liu and Chunfei Hu
Microfluidic chips offer the unique opportunity to establish novelty in vitro cells models where the in vivo cells microenvironment could be precisely reconstituted. Although they have significances in the fields of cell biology, the real applications are extremely limited by ambient materials for cells culture, i.e., cells morphology and migration are greatly influenced by substrate material. In this study, we investigated the cells migration effects in four kinds of microfluidic chips with the same geometry. They are PDMS mold structures bonded on culture dish, glass slide, and PDMS substrates, respectively, and another PMMA mold structure bonded on PMMA substrate. For convenient description, we denoted these four chips as PDMS-DISH, PDMS-GLASS, PDMS-PDMS, and PMMA-PMMA, respectively. We compared and summarized the relationship of cells migration effects on different substrate. The .. View More»
DOI:
10.4172/2157-7064.1000345