Journal of Chromatography & Separation Techniques
Open Access
ISSN: 2157-7064
ISSN: 2157-7064
Yun J
Republic of Korea
Research Article
Detection of Synthetic Anti-Obesity Drugs, Designer Analogues and Weight- Loss Ingredients as Adulterants in Slimming Foods from 2015 to 2017
Author(s): Yun J, Choi J, Jo C.H and Kwon KYun J, Choi J, Jo C.H and Kwon K
Obesity is a chronic disease associated with serious health problem such as metabolic syndrome, diabetes, hypertension, and cardiovascular disease. Recently, anti-obesity drugs, designer analogues and natural weight-loss ingredients have been found in dietary supplements for rapid weight loss or maintenance. In addition, structurally modified designer analogues are being continuously synthesized to avoid governmental inspections. 25 illegal compounds were assayed using a liquid chromatography coupled with photodiode array detector (LC-PDA) and tandem mass spectrometry (UPLC-MS/MS) analyses. A simultaneous determination method was established and fully validated. In 76 of 370 samples, nine different adulterants were detected including yohimbine, followed by β-phenylethylamine (β-PEA), sibutramine, sennoside A and B, β-methyl phenylethylamine (BMPEA), fluoxetine, ephedrin.. View More»
DOI:
10.4172/2157-7064.1000396