Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
+44 1223 790975
ISSN: 0974-276X
+44 1223 790975
YuhâSeog Jung
Republic of Korea
Research Article
Lipid MALDI MS Profiling Accurately Distinguishes Papillary Thyroid
Carcinoma from Normal Tissue
Author(s): Junsun Ryu, Geul Bang, Jeong Hwa Lee, Seung Ho Choi, YuhâSeog Jung, Kwang Pyo Kim, Young Hwan Kim and Hark Kyun KimJunsun Ryu, Geul Bang, Jeong Hwa Lee, Seung Ho Choi, Yuh–Seog Jung, Kwang Pyo Kim, Young Hwan Kim and Hark Kyun Kim
Background: Histology-directed tissue Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI MS) has been used to identify lipid profiles that can distinguish cancerous epithelium from normal epithelium.
Methods: In order to evaluate if lipid profiles may assist with diagnosis, frozen resected tumor samples collected from papillary thyroid carcinoma patients were analyzed using Matrix (DHB/CHCA)-Assisted Laser Desorption/ Ionization (MALDI) Mass Spectrometry (MS), together with adjacent normal tissue samples.
Results: Lipid peaks differentially expressed between cancer and normal samples at a feature selection P<0.001 correctly predicted class labels of test set samples (7 pairs) in 100 random training-to-test partitions, at the median class prediction accuracy of 100%. In addition, lipid peaks dif.. View More»
DOI:
10.4172/jpb.1000263