Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Waleed Khalifa
Israel
Research Article
Selection of Significant Clusters of Genes based on Ensemble Clustering and Recursive Cluster Elimination (RCE)
Author(s): Loai Abdallah, Waleed Khalifa, Louise C Showe and Malik YousefLoai Abdallah, Waleed Khalifa, Louise C Showe and Malik Yousef
Background: Advances in technology have facilitated the generation of gene expression data from large numbers of samples and the development of “Big Data” approaches to analysing gene expression in basic and biomedical systems. That being said, the data still includes relatively small numbers of samples and tens of thousands of variables/gene expression. A variety of different approaches have been developed for searching these gene spaces in order to select the most informative variables that can accurately distinguish one class of subjects/ samples from another. However, there is still a need for new approaches that can accurately distinguish biologically different classes of subjects with similar gene expression profiles. We describe a new and promising approach for selecting the most informative differentially expressed genes that addresses this problem.. View More»
DOI:
10.4172/jpb.1000439