Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
+44 1223 790975
ISSN: 0974-276X
+44 1223 790975
Vladislav V. Khrustalev
Belarus, Minsk,
220029, Communisticheskaya 7-24
Belarus
Research Article
Main Pathways of Proteome Simplification in Alphaherpesviruses Under the Influence of the Strong Mutational GC-pressure
Author(s): Vladislav V. Khrustalev and Eugene V. BarkovskyVladislav V. Khrustalev and Eugene V. Barkovsky
The simplification of amino acid content distribution under the influence of the strong mutational pressure takes place in simplex and varicello viruses proteins coded by genes with GC-content higher than 60%. We proved this statement by the way of in-silico calculation of Shannon’s entropy of amino acid content distribution in all proteins from ten completely sequenced simplex and varicello viruses. Entropy of amino acid content distribution decreases because of the growth of GARP (glycine, alanine, arginine and proline) usage due to the decrease not only in FYMINK (phenylalanine, tyrosine, methionine, isoleucine, asparagine and lysine) but also in other amino acids (coded by codons with average GC-content) usages. Threonine, serine, glutamine and cysteine are frequently substituted to GARP in proteins coded by genes with G+C higher than 60% (threonine and seri.. View More»
DOI:
10.4172/jpb.1000065