Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
+44 1223 790975
ISSN: 0974-276X
+44 1223 790975
Vijay Thiruvenkatam
Department of Biological Engineering Indian Institute of Technology Gandhinagar,
Ahmedabad-382424, Gujarat
India
Research Article
Structural Investigation and In-silico Characterization of Plasmepsins
from Plasmodium falciparum
Author(s): Divya N. Nair, Vijay Singh, Deekshi Angira and Vijay ThiruvenkatamDivya N. Nair, Vijay Singh, Deekshi Angira and Vijay Thiruvenkatam
Malaria is the one most important parasitic disease of humans, which affects approximately one hundred countries and threatens half of the world’s population. The Plasmodium aspartic protease called plasmepsins performs a vital role in providing nutrients to the malaria parasite, which make these proteins as an excellent drug target. In this study, we have carried out a comparative protein modeling, active site analysis and structural analysis of all ten plasmepsins from Plasmodium falciparum. In this report we have analyzed in-silico structure modeling and made efforts to characterize plasmepsins structure and further propose its functional information. The phylogenetic analysis and disulfide linkages indicate, plasmepsin I to IV and HAP have similar structure, function property. Whereas, plasmepsin IX to X and.. View More»
DOI:
10.4172/jpb.1000405