Journal of Proteomics & Bioinformatics

Journal of Proteomics & Bioinformatics
Open Access

ISSN: 0974-276X

+44 1223 790975

V. Janardhana Rao

  • Research Article
    Functional Protein Analysis of Hypertriglyceridemia: A Bioinformatic Approach
    Author(s): V. Srinivasa Rao, Sussant Kumar Das and V. Janardhana RaoV. Srinivasa Rao, Sussant Kumar Das and V. Janardhana Rao

    Hypertriglyceridemia is defined as an abnormal concentration of triglycerides in blood and is a commonly encountered lipid abnormality frequently associated with other lipid and metabolic derangements. Prolonged hypertriglyceridemia may produce neuropathological and abnormal metabolic changes particularly in peripheral sensory nerves. In the present study, we evaluated the role of several proteins that are likely to be involved in hypertriglyceridemia by employing multiple sequence alignment using ClustalW tool and constructed a phylogenic tree using functional protein sequences extracted from NCBI. The phylogeny tree was constructed with Neighbor Joining Algorithm using bioinformatic principles and applications. The association of apolipoprotein C-II, proinsulin, fatty acid binding protein, sterol regulatory element binding transcription factor, angiotensin I converting enzyme, lipin.. View More»
    DOI: 10.4172/jpb.1000015

    Abstract PDF

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