Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
+44 1223 790975
ISSN: 0974-276X
+44 1223 790975
Ten-Yang Yen
Tanzania
Research Article
Mining the Breast Cancer Proteome for Predictors of Drug Sensitivity
Author(s): Leslie C Timpe, Dian Li, Ten-Yang Yen, Judi Wong, Roger Yen, Bruce A Macher and Alexandra PiryatinskaLeslie C Timpe, Dian Li, Ten-Yang Yen, Judi Wong, Roger Yen, Bruce A Macher and Alexandra Piryatinska
Approximately 20 drugs have been approved by the FDA for breast cancer treatment, yet predictive biomarkers are known for only a few of these. The identification of additional biomarkers would be useful both for drugs currently approved for breast cancer treatment and for new drug development. Using glycoprotein expression data collected via mass spectrometry, in conjunction with statistical models constructed by elastic net or lasso regression, we modeled quantitatively the responses of breast cancer cell lines to ~90 drugs. Lasso and elastic net regression identified HER2 as a predictor protein for lapatinib, afatinib, gefitinib and erlotinib, which target HER2 or the EGF receptor, thus providing an internal control for the approach. Two additional protein datasets and two RNA datasets were also tested as sources of predictor proteins for modeling drug sensitivity. Protein expr.. View More»
DOI:
10.4172/jpb.1000370