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Using Proteomics to Understand Abdominal Aortic Aneurysms: Where Are We?
Author(s): Tania Gamberi, Alessandra Modesti, Francesca Magherini, Tania Fiaschi, Elisa Valocchia, Merry L Lindsey and Pietro Amedeo ModestiTania Gamberi, Alessandra Modesti, Francesca Magherini, Tania Fiaschi, Elisa Valocchia, Merry L Lindsey and Pietro Amedeo Modesti
Proteomics have been widely used to investigate potential biomarkers in a variety of diseases. Aortic aneurysm is an increasingly common vascular disorder with frequently fatal implications. However, there is no established diagnosis other than the one based on aneurysmal size. Despite widespread investigation, biomarkers for abdominal aortic aneurysms (AAA) development, progression and rupture are still lacking. A proteomic approach could reveal novel biomarkers. MEDLINE/PubMed and EMBASE were searched with the medical subject heading abdominal aortic aneurysm and keywords: size, rupture and expansion rate and proteomics. Studies investigating the association among AAA expansion, rupture or size with tissue, secretome and circulating biomarkers using proteomics were selected. Sixteen papers were identified. To summarize the data pointed out by these papers, we classified into functio.. View More»