Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
+44 1223 790975
ISSN: 0974-276X
+44 1223 790975
Takeshi Kikuchi
College of Life Sciences,
1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577
Japan
Research Article
Properties of Amino Acid Sequences of Lysozyme-Like Superfamily Proteins Relating to Their Folding Mechanisms
Author(s): Takuto Nakashima, Michirou Kabata and Takeshi KikuchiTakuto Nakashima, Michirou Kabata and Takeshi Kikuchi
It is expected that we can predict the mechanism of folding of a protein from only its sequence if the information about the folding is encoded in the sequence. This is a long standing problem in molecular biophysics and molecular bioinformatics. In this study, we examine the folding of the lysozyme-like superfamily proteins that diverged from a common ancestor protein and show the common function and partially common 3D topology. We use methods based on inter-residue average distance statistics and evolutionary analysis to identify the location of the folding region from only their amino acid sequence. The properties of these sequences indicate that the general folding mechanisms are common among proteins in the same family. The difference in the folding mechanisms between the lysozymes in the animal kingdom and that in λ-phage are also suggested. We compare the hydrophobic pa.. View More»
DOI:
10.4172/jpb.1000429