Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Tadashi Kondo
Proteome Bioinformatics Project, National Cancer Center Research Institute,
5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045
Japan
Research Article
Cancer Proteomics for Biomarker Development
Author(s): Tadashi KondoTadashi Kondo
Cancer is a diverse disease, and biomarkers reflecting this diversity will lead to better therapeutic strategies. By linking proteomic data and clinico-pathological parameters, we are identifying proteins informative for features of clinical relevance to cancer patients. To obtain proteome data, we developed a large format system for two-dimensional difference gel electrophoresis and an application of highly sensitive fluorescent dye for laser microdissection. Following the comprehensive proteome study of more than 1,000 surgical specimens and corresponding clinico-pathological data, we concluded that the proteome reflects the major cancer phenotypes such as histological differentiation, poor prognosis, and response to treatment. Furthermore, we found that certain single proteins predict the clinical outcome in many types of malignancies including esophageal cancer, l.. View More»
DOI:
10.4172/jpb.1000055