Journal of Proteomics & Bioinformatics

Journal of Proteomics & Bioinformatics
Open Access

ISSN: 0974-276X

+44 1223 790975

Tadashi Kondo

Tadashi Kondo
Proteome Bioinformatics Project, National Cancer Center Research Institute,
5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045

  • Research Article
    Cancer Proteomics for Biomarker Development
    Author(s): Tadashi KondoTadashi Kondo

    Cancer is a diverse disease, and biomarkers reflecting this diversity will lead to better therapeutic strategies. By linking proteomic data and clinico-pathological parameters, we are identifying proteins informative for features of clinical relevance to cancer patients. To obtain proteome data, we developed a large format system for two-dimensional difference gel electrophoresis and an application of highly sensitive fluorescent dye for laser microdissection. Following the comprehensive proteome study of more than 1,000 surgical specimens and corresponding clinico-pathological data, we concluded that the proteome reflects the major cancer phenotypes such as histological differentiation, poor prognosis, and response to treatment. Furthermore, we found that certain single proteins predict the clinical outcome in many types of malignancies including esophageal cancer, l.. View More»
    DOI: 10.4172/jpb.1000055

    Abstract PDF

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