Journal of Proteomics & Bioinformatics

Journal of Proteomics & Bioinformatics
Open Access

ISSN: 0974-276X

Su Yeon Kim

Su Yeon Kim
Center for Immunology and Pathology, Korea National Institute of Health, Centers for Disease Control and Prevention,
Cheongju-si, Chungcheongbuk-do, 28159
Republic of Korea

  • Research Article
    Proteomics-based Development of Biomarkers for Prion Diseases
    Author(s): Bo-Yeong Choi, Yeong Seon Lee, Young Ran Ju, Chi-Kyeong Kim and Su Yeon KimBo-Yeong Choi, Yeong Seon Lee, Young Ran Ju, Chi-Kyeong Kim and Su Yeon Kim

    We analyzed the proteomic profile of ME7 scrapie-infected mouse brains, and the interactions and functions of selected differentially expressed proteins to identify potential new biomarkers to be applicable for the diagnosis of Prion diseases. Mice were intracerebrally inoculated with 10% homogenate of ME7 scrapie-infected mouse brains, and monitored for neurological symptoms. We screened for proteins specifically expressed in infected brain samples using one-dimensional gel electrophoresis and liquid chromatography-mass spectrometry. 317 proteins based on their peptide scores and ratio values were selected. The major biological processes identified were cellular and metabolic processes, localization, and transport. Selected proteins had functions related to neurological processes, including cell-cell signaling, transmission of nerve impulse, and synaptic transmission. We analyzed inf.. View More»
    DOI: 10.4172/jpb.1000394

    Abstract PDF

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