Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Sivakama Valli . J
India
Research Article
In silico Homology Modeling of Prophenoloxidase activating factor Serine Proteinase Gene from the Haemocytes of Fenneropenaeus indicus
Author(s): Baskaralingam Vaseeharan and Sivakama Valli . JBaskaralingam Vaseeharan and Sivakama Valli . J
In invertebrates, immune system consist of encapsulation, phagocytosis, and nodule formation while humoral responses includes clotting, synthesis of antimicrobial peptides, and activation of the Prophenoloxidase (proPO) system. Serine proteinases (SPs) constitute one of the largest families of proteolytic enzymes involved in the activation of Prophenoloxidase. The major feature of serine proteinase is interlinked by three pairs of conserved disulfide bridges. Although the exact function of the clip domain presently remains unclear, there are certain speculations about its function. The present study reports the three-dimensional structures of novel immune related gene serine proteinase predicted by in silico homology modelling studies. Physico-chemical characterization interprets properties such as pI, EC, AI, GRAVY and instability index and provides valuable data about this clip doma.. View More»
DOI:
10.4172/jpb.1000166