Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Sibaji Sarkar
Cancer Center, Genome Science Institute,
MA
Tanzania
Research Article
Methylation by DNMT1 is more Efficient in Chronic Lymphocytic
Lymphoma Cells than in Normal Cells
Author(s): Eric Samorodnitsky, Emily Ghosh, Sahana Mazumder and Sibaji SarkarEric Samorodnitsky, Emily Ghosh, Sahana Mazumder and Sibaji Sarkar
Binding of activators and repressors plays a significant role in transcriptional regulation of gene expression. The systems biology approach has been applied to predict and determine the efficiency of this process; however, most of the work is done in prokaryotic systems. Epigenetic regulation provides another dimension of transcriptional regulation, which does not involve changes in the coding region of genes. Methylation of specific CpG residues in the CpG islands of DNA by the enzyme DNA methyl transferase 1 (DNMT1) causes gene silencing. In cancer cells, the enzyme DNMT1 is highly expressed, and the methylation level at specific sites of genes, including tumor suppressor genes, is elevated. This results in the silencing of tumor suppressor genes for carcinogenesis. However, it is not known whether the increase in DNMT1 expression is proportional to the increase in the level of met.. View More»
DOI:
10.4172/jpb.S10-004