Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Shigeru Takasaki
Izumino 1-1-1, Ouragun Itakuracho, Gunma 374-0193
Japan
Research Article
Mitochondrial Haplogroups Associated with Japanese Centenarians,
Alzheimer’s Patients, Parkinson’s Patients, Type 2 Diabetes Patients,
Healthy Non-Obese Young Males, and Obese Young Males
Author(s): Shigeru TakasakiShigeru Takasaki
There are strong connections among mitochondria, aging, and a wide variety of diseases. In this paper, the relations between eight classes of Japanese people-96 centenarians, 112 semi-supercentenarians (over 105 years old but less than 116 years old), 96 Alzheimer's disease (AD) patients, 96 Parkinson's disease (PD) patients, 96 type 2 diabetes (T2D) patients, 96 T2D patients with angiopathy, 96 healthy non-obese young males and 96 healthy obese young males-and their mitochondrial single nucleotide polymorphism (mtSNP) frequencies at individual mtDNA positions of the entire mitochondrial genome were examined using the radial basis function (RBF) network and a modified RBF method. New findings of mitochondrial haplogroups were obtained for individual classes. The centenarians were found to be associated with the haplogroups D4b2a, B5b, and M7b2; the semi-supercentenarinas with B4c1a, F.. View More»
DOI:
10.4172/jpb.1000175