Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Privita Verma
India
Research Article
In-silico Approach Explains Evolution of Beta-lactamases from Penicillin
Binding Proteins
Author(s): Privita Verma, Aditi Upadhyay, Monalisa Tiwari and Vishvanath TiwariPrivita Verma, Aditi Upadhyay, Monalisa Tiwari and Vishvanath Tiwari
Penicillin binding proteins (PBPs) possess transpeptidase, transglycosylase as well as carboxypeptidase activities and mediates the crosslinking of N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM) of peptidoglycan, thereby promoting the cell wall synthesis. The β-lactam antibiotics bind to PBPs and inactivate them, thus killing the bacteria. During the course of evolution, bacteria have also developed differential survival strategies. Emergence of multidrug resistance resulting from β-lactamases constitutes a worldwide threat. This enzyme hydrolyzes β-lactam antibiotics and thus makes them inactive. The purpose of this study was to analyze the binding affinity of β-lactam antibiotics with PBPs and β-lactamases by computational docking studies. For this, different classes of β-lactams know.. View More»
DOI:
10.4172/jpb.1000413