Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
+44 1223 790975
ISSN: 0974-276X
+44 1223 790975
Preeti Srivastava
School of Biotechnology, Faculty of Science, Banaras Hindu University,
Varanasi-221005, Uttar Pradesh
India
Research Article
Screening and Identification of Salicin Compound from Desmodium gangeticum and its In vivo Anticancer Activity and Docking Studies with Cyclooxygenase (COX) Proteins from Mus musculus
Author(s): Preeti Srivastava, Vinay K Singh, Brahma Deo Singh, Gaurava Srivastava, Bhuwan B Misra and Vyasji TripathiPreeti Srivastava, Vinay K Singh, Brahma Deo Singh, Gaurava Srivastava, Bhuwan B Misra and Vyasji Tripathi
Cancer continues to be a worldwide killer, despite the enormous amount of research and rapid developments seen during the past decade. It has been suggested that by 2020 more than 15 million new cases of cancer will be diagnosed. Since it is commonly believed that many are preventable, there is urgent need to identify/develop natural medicines as effective chemopreventive agents. The purpose of this current study was to assess the effect of isolated and characterized salicin on cyclooxygenase (COX) proteins by molecular docking studies and by assessments of the effects of drug-ligand interaction. Salicin isolated from Desmodium gangeticum, a medicinal legume, is a COX inhibitor. The present study report the extraction, isolation and identification of salicin and its interaction with COX-1 and COX-2 derivatives, which .. View More»
DOI:
10.4172/jpb.1000269