Journal of Proteomics & Bioinformatics
Open Access

Piotr Zielenkiewicz

Publications

• Research Article
  Protein Interaction Network. Double Exponential Model
  Author(s): Piotr H. Pawlowski, Szymon Kaczanowski and Piotr ZielenkiewiczPiotr H. Pawlowski, Szymon Kaczanowski and Piotr Zielenkiewicz
  
  The proper theoretical description of the distribution of the node degree for yeast protein-protein interaction network was investigated to deal with the observed discrepancy between usually proposed models and the existing data. The power law or the generalized power law with exponential cut-off were shown to be inaccurate within a wide range of degree values. Proposed linear-combination-of-exponentialdecays- method exactly characterizing the distribution by the spectrum of decay constants revealed two separate parameter domains. A consequent hypothesis that the node degree distribution could follow the universal double exponential law was successfully verified by selected model comparison using the AIC criterion. BIND and DIP data for H. pylori, E. coli, S. cerevisiae, D. melanogaster, C. elegans and A. thaliana were used for this purpose. A linear change in the mag.. View More»
  DOI: 10.4172/jpb.1000010

  Abstract PDF

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