Journal of Proteomics & Bioinformatics

Journal of Proteomics & Bioinformatics
Open Access

ISSN: 0974-276X

+44 1223 790975

Piotr Zielenkiewicz

  • Research Article
    Protein Interaction Network. Double Exponential Model
    Author(s): Piotr H. Pawlowski, Szymon Kaczanowski and Piotr ZielenkiewiczPiotr H. Pawlowski, Szymon Kaczanowski and Piotr Zielenkiewicz

    The proper theoretical description of the distribution of the node degree for yeast protein-protein interaction network was investigated to deal with the observed discrepancy between usually proposed models and the existing data. The power law or the generalized power law with exponential cut-off were shown to be inaccurate within a wide range of degree values. Proposed linear-combination-of-exponentialdecays- method exactly characterizing the distribution by the spectrum of decay constants revealed two separate parameter domains. A consequent hypothesis that the node degree distribution could follow the universal double exponential law was successfully verified by selected model comparison using the AIC criterion. BIND and DIP data for H. pylori, E. coli, S. cerevisiae, D. melanogaster, C. elegans and A. thaliana were used for this purpose. A linear change in the mag.. View More»
    DOI: 10.4172/jpb.1000010

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