Journal of Proteomics & Bioinformatics

Journal of Proteomics & Bioinformatics
Open Access

ISSN: 0974-276X

+44 1223 790975

Payal Agarwal

Publications
  • Research Article
    In-silico Approaches for Studying Cross-talk of Different Kinases Associated in Diverse Biological Processes with their Interacting Substrates Partners
    Author(s): Gohar Taj, Payal Agarwal and Anil KumarGohar Taj, Payal Agarwal and Anil Kumar

    The Signal transduction pathway uses docking interaction with kinases which may also be regulated by phosphorylation. Regulation of these docking interactions by phosphorylation allows an additional level of control over the diverse biological processes including Crosstalk induction of defense. Amino acid sequences surrounding the phosphorylation motif have been extensively studied. However, the present study, attempts have been made to identify the presence of important determinants/motifs for substrate specificity of Mitogen activated protein kinase (MAPK), CaM kinase II, Protein kinase C, Receptor tyrosine kinase in the 54 identified MAPK 3 and MAPK 6 substrates of Arabidopsis thaliana. All identified substrates do not possess the known (p) S/ (p) T-P phosphorylation sites. Out of 54 substrates, 47 have S/T-P site and 7 are lacking such sites for interaction. Likewise 8 shows XXRRX.. View More»
    DOI: 10.4172/jpb.1000173

    Abstract PDF

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