Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Pascal Roy
France
Research Article
Impact of the Selection Mechanism in the Identification and Validation of New "Omic" Biomarkers
Author(s): Caroline Truntzer, Delphine Maucort-Boulch and Pascal RoyCaroline Truntzer, Delphine Maucort-Boulch and Pascal Roy
Background: High throughput analysis like mass spectrometry dedicated to clinical proteomics offers new insights into clinical research. This promising technology generates high-dimensional datasets with a huge amount of biological input. Working with these high-dimensional datasets has created challenges for statistical methods and there are still weaknesses in current statistical analysis that have to be overcome to get an accurate interpretation of “omics” studies. The central question is that of a reliable identification of new prognostic and diagnostic biomarkers. Although observed in previous studies, these mechanisms of identification and validation of new markers have been inadequately explained and often dissociated.
Results: The aim of our study was therefore to show how candidate markers are sometimes selected in ident.. View More»
DOI:
10.4172/jpb.1000276