Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
+44 1223 790975
ISSN: 0974-276X
+44 1223 790975
Oliver Schmitt
Gertrudenstraße 9, 18055 Rostock,
Germany
Research Article
Differential Proteomics of the Cerebral Cortex of Juvenile, Adult and Aged Rats: An Ontogenetic Study
Author(s): Michael Wille, Antje Schümann, Michael Kreutzer, Michael O Glocker, Andreas Wree, Grit Mutzbauer and Oliver SchmittMichael Wille, Antje Schümann, Michael Kreutzer, Michael O Glocker, Andreas Wree, Grit Mutzbauer and Oliver Schmitt
The identification of up- and downregulated as well as absent proteins in the central nervous system is necessary to understand the interplay of migration, differentiation and integration of neuronal progenitor cells at different stages of development. In a first step, differentially expressed proteins of the cerebral cortex of the laboratory rat at three significant stages of development were identified. The cerebral cortex needs differential abundances of proteins during ontogenesis and uses its high plasticity postnatally to adapt to many types of intrinsic and extrinsic changes. This study focuses on the identification of specific proteins which are differentially expressed during postnatal development. Cerebral cortices of P7, P90 and P637 old wistar rats were dissected and analyzed by twodimensional polyacrylamide gel electrophoresis (2DE) and matrix-assisted laser desorption/io.. View More»
DOI:
10.4172/jpb.1000424