Journal of Proteomics & Bioinformatics
Open Access

Octávio L. Franco

Publications

• Review Article
  Elucidating Novel Bacterial Targets and Designing Unusual Antimicrobial Peptides: Two Faces of the Same Proteomic Coin
  Author(s): Octávio L. FrancoOctávio L. Franco
  
  Antibiotics are essential compounds used for the control of bacterial infectious diseases. Resistance to antibiotics has become a worldwide public health problem. Therefore, effective therapy in treating resistant bacteria is essential and, to accomplish this, a comprehensive understanding of mechanisms that trigger drug resistance must be sought. The development of novel pharmacies, here focused on antimicrobial peptides (AMPs), has also been a remarkable challenge. To fill the manifold gaps that remain in clarifying bacterial resistance as well in the discovery of novel peptides with antimicrobial properties, proteomic tools have been pioneeringly used. In this context, this review focuses on novel proteomics techniques, on novel bacterial targets that could be used for drug design and on multiple AMPs found in different organisms. Moreover, the many difficulties and pitfalls in thi.. View More»
  DOI: 10.4172/jpb.S8-001

  Abstract PDF

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