Pediatrics & Therapeutics
Open Access
ISSN: 2161-0665
+44 1478 350008
ISSN: 2161-0665
+44 1478 350008
Noel Cranswick
Royal Children’s Hospital,
Flemington Rd, Parkville VIC 3052
Australia
Research Article
Polyethylene Glycols with or without Electrolytes for Constipation in Children: A Network Meta-Analysis
Author(s): George Krassas, Noel Cranswick, Peter Katelaris, Vasi Naganathan, John Gullotta and Ken LiuGeorge Krassas, Noel Cranswick, Peter Katelaris, Vasi Naganathan, John Gullotta and Ken Liu
Background: Polyethylene glycol laxatives are the cornerstone of the management of constipation in children. They are available with and without electrolytes.Aims: The aims of this network meta-analysis (NMA) were to assess the relative efficacy, safety and tolerability of polyethylene glycol with (PEG+E) or without electrolytes (PEG) in the management of constipation in children.Methods: A systematic review and NMA was undertaken to identify and analyse all published randomised controlled clinical trials of polyethylene glycol in children with constipation. Text word searches were carried out using MEDLINE, MEDLINE in Progress, EMBASE, Cochrane Database and Systematic Reviews databases covering inception to April 2015. The primary efficacy analysis was the mean number of bowel movements per week. Secondary endpoints asses.. View More»
DOI:
10.4172/2161-0665.1000344