Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
+44 1223 790975
ISSN: 0974-276X
+44 1223 790975
Mehwish Munir
Pakistan
Research Article
Species-Wide Genome Mining of Pseudomonas putida for Potential Secondary Metabolites and Drug-Like Natural Products Characterization
Author(s): Sara Aiman, Muhammad Shehroz, Mehwish Munir, Sahib Gul, Mohibullah Shah and Asifullah KhanSara Aiman, Muhammad Shehroz, Mehwish Munir, Sahib Gul, Mohibullah Shah and Asifullah Khan
The gram negative bacteria species of Pseudomonas putida (P. putida) are important for heterologous expression of diverse biosynthetic pathways and numerous secondary metabolites biosynthesis. The genes code for such secondary metabolites biosynthetic proteins are organized in microbial genomes as clusters to bring the concerted expression of entire biosynthetic machinery. The complete and whole genome sequences of more than fifty different strains available in public DNA sequences databases provide an excellent opportunity to investigate the genetically encoded secondary metabolites potential of ecologically diverse P. putida strains. We implement the advance bioinformatics resources to annotate the so far available P. putida strains genomes for biosynthetic gene clusters (BGCs) and underlie secondary metabolites chemical scaffolds. The P. puida strains are found to harbor genomic si.. View More»
DOI:
10.4172/jpb.1000460