Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
+44 1223 790975
ISSN: 0974-276X
+44 1223 790975
Mathias Uhlén
Royal Institute of Technology (KTH) ,
Science for Life Laboratory, Stockholm
Sweden
Research Article
Tissue-Specific Protein Expression in Human Cells, Tissues and Organs
Author(s): Marcus Gry, Per Oksvold, Fredrik Pontén and Mathias UhlénMarcus Gry, Per Oksvold, Fredrik Pontén and Mathias Uhlén
An important part of understanding human biology is the study of tissue-speci fi c expression both at the gene and protein level. In this study, the analysis of tissue speci fi c protein expression was performed based on tissue micro array data available on the public Human Protein Atlas database (www.proteinatlas.org). An analysis of human proteins, corresponding to approximately one third of the protein-encoding genes, was carried out in 65 human tissues and cell types. The spatial distribution and relative abundance of 6,678 human proteins, were analyzed in different cell populations from various organs and tissues in the human body using unsupervised methods, such as hierarchical clustering and principal component analysis, as well as with supervised methods (Breiman, 2001). Well-known markers, such as neuromodulin for the central nervous system, .. View More»
DOI:
10.4172/jpb.1000153