Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Limpon Bora
Tezpur- 784028
India
Research Article
Homology Modeling and Docking to Potential Novel Inhibitor for Chikungunya (37997) Protein nsP2 Protease
Author(s): Limpon BoraLimpon Bora
Chikungunya is viral disease is transmitted to human beings by mosquito bite. Chikungunya can cause fever, chills, nausea, vomiting, joint pain, head ache, and swollen in the joints. A cause of Chikungunya is mainly due to the replication of Chikungunya virus in the human body. The nsP2 (non structural Protein 2) protein is responsible for Chikungunya virus replication. CHIKV replication causes general host shut-off. CHIKV replication is resistant to inhibition by interferon once RNA replication has been established and that CHIKV actively suppress the antiviral IFN response by preventing IFN-induced gene expression. Chikungunya virus replication and propagation is dependent on the protease activity of the viral nsP2 protein, which cleaves the nsP1234 polyprotein replication complex into functional unit This study investigates about the nsP2 .. View More»
DOI:
10.4172/jpb.1000213