Journal of Proteomics & Bioinformatics

Journal of Proteomics & Bioinformatics
Open Access

ISSN: 0974-276X

+44 1223 790975

Limpon Bora

Limpon Bora

Tezpur- 784028

  • Research Article
    Homology Modeling and Docking to Potential Novel Inhibitor for Chikungunya (37997) Protein nsP2 Protease
    Author(s): Limpon BoraLimpon Bora

    Chikungunya is viral disease is transmitted to human beings by mosquito bite. Chikungunya can cause fever, chills, nausea, vomiting, joint pain, head ache, and swollen in the joints. A cause of Chikungunya is mainly due to the replication of Chikungunya virus in the human body. The nsP2 (non structural Protein 2) protein is responsible for Chikungunya virus replication. CHIKV replication causes general host shut-off. CHIKV replication is resistant to inhibition by interferon once RNA replication has been established and that CHIKV actively suppress the antiviral IFN response by preventing IFN-induced gene expression. Chikungunya virus replication and propagation is dependent on the protease activity of the viral nsP2 protein, which cleaves the nsP1234 polyprotein replication complex into functional unit This study investigates about the nsP2 .. View More»
    DOI: 10.4172/jpb.1000213

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