Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Krysta N. Greenleaf
Tanzania
Research Article
Antibody Microarray Analysis of Signaling Networks Regulated by Cxcl13
and Cxcr5 in Prostate Cancer
Author(s): Christelle P. El-Haibi, Rajesh Singh, Pranav Gupta, Praveen K. Sharma, Krysta N. Greenleaf, Shailesh Singh and James W. Lillard JrChristelle P. El-Haibi, Rajesh Singh, Pranav Gupta, Praveen K. Sharma, Krysta N. Greenleaf, Shailesh Singh and James W. Lillard Jr
Advanced prostate cancer (PCa) often spreads to distant organs, leading to increased morbidity and mortality. It is now well established that chemokines and their cognate receptors play a crucial role in the multi-step process of metastasis. We have previously identified CXCR5 to be highly expressed by PCa tissues and cell lines and its specific ligand, CXCL13, is significantly elevated in the serum of patients with PCa and differentiated PCa cases with other benign prostatic diseases. CXCR5:CXCL13 interactions promote PCa cell invasion, migration, and differential matrix metalloproteinase (MMP) expression. Thus, it is important to understand the molecular and cellular processes that mediate these events. In this study, we quantified changes in apoptosis, cell cycle, and cytoskeleton rearrangement biological pathways from CXCL13-treat.. View More»
DOI:
10.4172/jpb.1000232