Journal of Drug Metabolism & Toxicology
Open Access
ISSN: 2157-7609
ISSN: 2157-7609
Jitendra Kumar Singh
In vitro Pharmacology Laboratory, Gujarat,
India
Research Article
Comparative in-vitro Intrinsic Clearance of Imipramine in Multiple Species Liver Microsomes: Human, Rat, Mouse and Dog
Author(s): Jitendra Kumar Singh, Anant Solanki and Vikas S. ShirsathJitendra Kumar Singh, Anant Solanki and Vikas S. Shirsath
Imipramine is a renowned tricyclic anti-depressant molecule. It is known to be highly potent and efficient as compared to any other antidepressants available. There are numerous literature reports which elucidate the metabolic pathways of Imipramine. There are also various reports showing the effect of substrate and time on metabolism of Imipramine. Most of analytical methods used in these studies were of HPLC and /or of LC-MS. These studies have also been extended to identification of specific isoforms of cytochrome P450 family responsible for the metabolism of Imipramine as is outlined. Further, LC-MS based studies have also been reported on the metabolism of Imipramine in in-vitro systems including human liver microsomes and its extrapolation on human oral bioavailability data. However, till date, there has been no published report on the systematic metabolic stabi.. Read More»
DOI:
10.4172/2157-7609.1000126
