Chronic use of alcohol leads to fluctuations in brain chemistry, especially in the GABAergic system. Various variations occur such as changes in gene expression and down-regulation of GABAA receptors. During acute alcohol withdrawal, changes also occur such as upregulation of alpha4 containing GABAA receptors and down-regulation of alpha1 and alpha3 containing GABAA receptors. Neurochemical changes occurring during alcohol withdrawal can be minimized with drugs which are used for acute detoxification.
Related journals on Alcoholism and genetics
Drug and Alcohol Dependence, Alcoholism Journal, Sleep Disorders & Therapy, Alcoholic liver disease Postgraduate Medical Journal, Addiction Research & Therapy, The Journal of Hepatology, Depression and Anxiety, Alcoholic Liver Disease, European Journal of Gastroenterology & Hepatology, Child and Adolescent Behavior, Continuing Education in Anaesthesia