Journal of Proteomics & Bioinformatics

Journal of Proteomics & Bioinformatics
Open Access

ISSN: 0974-276X

+44 1223 790975

Jiajia Chen

Jiajia Chen

China

Publications
  • Research Article
    Quantitative Profiling of Histone H3 Methylation in Human Hepatocellular Carcinoma
    Author(s): Jiajia Chen, Guoquan Yan, Fang Wang, Xuefei Yin, Hong Jin and Peng-yuan YangJiajia Chen, Guoquan Yan, Fang Wang, Xuefei Yin, Hong Jin and Peng-yuan Yang

    Alterations of epigenetics including DNA methylation and histone modifications play crucial roles in both initiation and progression of certain types of cancers. Abnormal histone modifications identified within these tumors represent potential biomarkers and therapeutic pathways. In this study, two different types of human hepatocellular carcinoma cell lines HepG2 and MHCC97-H with distinct metastasis capability are used to investigate the association of liver metastasis with cellular histone modification levels. In the HepG2 and MHCC97-H cells, 17 types of histone H3 modification corresponding to methylation are quantitatively profiled with LC coupled to high resolution mass spectrometry. Compared to HepG2 cells without metastasis capability, the combinatorial histone peptides of K9me1K14ac and K9me0K14ac in malignant MHCC97-H cells are found to be significantly down regulated, while.. View More»
    DOI: 10.4172/jpb.S2-003

    Abstract PDF

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