Journal of Proteomics & Bioinformatics
Open Access

Hyeon S. Son

Publications

• Research Article
  Validity of Protein Structure Alignment Method Based on Backbone Torsion Angles
  Author(s): Sunghoon Jung, Se-Eun Bae and Hyeon S. SonSunghoon Jung, Se-Eun Bae and Hyeon S. Son
  
  Previous researches noticed that a 3D backbone structure can be mathematically represented with a 1D ? and ? dihedral angle array. However, performance of the backbone dihedral angle alignment was not supported with sufficiently large test sets to be quantified; i.e. only 2 pairs or 4 pairs of proteins were analyzed. Here we showed that it is more effective to accurately anticipate homology among 1891 pairs of proteins of 62 different proteases with the string of ? and ? dihedral angle array than famous 3D structural alignment tool TM-align. Gapless global alignment between protein structures was conducted to validate the effectiveness of performing structural alignment with strings of backbone torsion angles. Representation of 3D structure by 1D torsion angle strings allows local alignment, profile construction, hidden Markov models to be implemented with minor modifications and with.. View More»
  DOI: 10.4172/jpb.1000192

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