Journal of Proteomics & Bioinformatics

Journal of Proteomics & Bioinformatics
Open Access

ISSN: 0974-276X

+44 1223 790975

Hojat Borna

Hojat Borna

West Indies

Publications
  • Research Article
    Evaluating New Targets of Natural Anticancer Molecules through Bioinformatics Tools
    Author(s): Mehrdad Hashemi, Iran, Newshan Behrangi and Hojat BornaMehrdad Hashemi, Iran, Newshan Behrangi and Hojat Borna

    Plants-derive compounds play crucial role in development of several anti-cancer drugs and they target proteins having significant regulatory effects on tumor cell cycle progress. Bioinformatics and cancer research overlap in many different areas in order to solve some problems in the field of treatment. In this study, the target and drug likeness of natural anticancer molecules are predicted by PASS software. Consequently, some new mechanisms of anticancer molecules have been introduced. They include Pseudobaptigenin with 0.702 PASS thresholds which revealed protein tyrosine kinase inhibitory. In addition, Kabophenol A and Carasinol B with score 0.652 and 0.669 respectively exhibited topoisomerase I inhibitory effects. Moreover, Docetaxel, 7-xylosyl-10-deacetyl paclitaxel and Artemether by exhibiting the highest PASS score are the strongest anticancer agents in our res.. View More»
    DOI: 10.4172/jpb.1000212

    Abstract PDF

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