Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
+44 1223 790975
ISSN: 0974-276X
+44 1223 790975
Gomase V.S
Padmashree Dr. D.Y. Patil University,
Plot No-50, Sector-15, CBD Belapur, Navi Mumbai, 400614
India
Research Article
Prediction of MHC Binding Peptides and Epitopes from Groundnut Bud Necrosis Virus (GBNV)
Author(s): Gomase V.S, Kale K.V and Shyamkumar KGomase V.S, Kale K.V and Shyamkumar K
A virus disease caused of crop losses to groundnut in Andhra Pradesh during kharif in the year 2000. It was presumed to be caused by Groundnut bud necrosis virus (GBNV), a virus known to be widely distributed in India. It is one among the important infestations affecting groundnut cultivation especially during summer. Nucleocapsid peptides of groundnut bud necrosis virus are most suitable for subunit vaccine development because with single epitope, the immune response can be generated in large population. Analysis shows MHC class II binding peptides of coat protein from SMV are important determinant for protection of many plants form viral infection. In this assay we predicted the binding affinity of SMV genome polyprotein having 276 amino acids, which shows 268 nonamers. In this analysis, we found the SVM based MHCII-IAb peptide regions, 171- PLAYYQNVK, 95- RTEAFIRTK.. View More»
DOI:
10.4172/jpb.1000024