Pediatrics & Therapeutics
Open Access

George Krassas

Publications

• Research Article
  Polyethylene Glycols with or without Electrolytes for Constipation in Children: A Network Meta-Analysis
  Author(s): George Krassas, Noel Cranswick, Peter Katelaris, Vasi Naganathan, John Gullotta and Ken LiuGeorge Krassas, Noel Cranswick, Peter Katelaris, Vasi Naganathan, John Gullotta and Ken Liu
  
  Background: Polyethylene glycol laxatives are the cornerstone of the management of constipation in children. They are available with and without electrolytes.Aims: The aims of this network meta-analysis (NMA) were to assess the relative efficacy, safety and tolerability of polyethylene glycol with (PEG+E) or without electrolytes (PEG) in the management of constipation in children.Methods: A systematic review and NMA was undertaken to identify and analyse all published randomised controlled clinical trials of polyethylene glycol in children with constipation. Text word searches were carried out using MEDLINE, MEDLINE in Progress, EMBASE, Cochrane Database and Systematic Reviews databases covering inception to April 2015. The primary efficacy analysis was the mean number of bowel movements per week. Secondary endpoints asses.. View More»
  DOI: 10.4172/2161-0665.1000344

  Abstract PDF

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