Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
+44 1223 790975
ISSN: 2155-9570
+44 1223 790975
Francisco Javier Carreras
Faculty of Medicine,
Avenida de la Investigación nº 11, 18016 Granada
Spain
Review Article
Glaucoma as a Tax on Hominid Evolution. Constraints of the Experimental Animal Models of Glaucoma
Author(s): Francisco Javier CarrerasFrancisco Javier Carreras
Glaucoma continues to be a mysterious disease. High intraocular pressure (IOP), once the landmark of the disease, has been relegated to the humble role of risk factor, despite the fact that lowering IOP continues to be the only partially successful treatment. Even with an IOP successfully controlled to statistical standards, many patients still mysteriously continue to progressively lose neural tissue. A novel pathogenetical mechanism has recently been put forward as the main agent of the disease. In this new light, some structural details of the human eye, the result of the peculiar evolutionary development, take on an unexpected role in the presentation of the disease. As results of cladistics analysis, the human eye appears as particularly prone to suffering glaucoma as a consequence of the evolutionary path taken. That makes glaucoma essentially a human (and related hominid) scour.. View More»
DOI:
10.4172/2155-9570.1000527