Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Filipa F. Vale
Estrada Octávio Pato, 2635-631 Rio de Mouro
Portugal
Research Article
Genomic Methylation Status for Discrimination Among Helicobacter Species: A Bioinformatics Approach
Author(s): Filipa F. Vale and Jorge M. B. VítorFilipa F. Vale and Jorge M. B. Vítor
The genus Helicobacter comprises several species of both gastric and enterohepatic intestinal bacteria. H. pylori, the type species of the genus, is associated with gastritis, peptic ulcer and gastric cancer in humans. H. pylori genome has a high number of restriction and modification (R-M) systems and their diversity is useful for strain typing. To analyse if such a high number of expressed methyltransferases is a characteristic of the genus Helicobacter, the genomic methylation of five non-pylori Helicobacter spp. (H. canadensis, H. canis, H. felis, H. mustelae and H. pullorum) was determined. The results revealed that the number of R-M systems among nonpylori Helicobacter spp. is smaller than those observed among a group of 221 H. pylori strains (p<0,001), but is greater than those observed for the mean of all bacteria sequenced genomes (p=0,005). 16S ribosomal .. View More»
DOI:
10.4172/jpb.1000033