Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
+44 1223 790975
ISSN: 0974-276X
+44 1223 790975
Şenay Kafkas
European Bioinformatics Institute, Wellcome Trust Genome Campus,
Cambridge, Hinxton, CB10 1SD
United Kingdom
Research Article
Diversity in the Interactions of Isoforms Linked to Clustered Transcripts: A Systematic Literature Analysis
Author(s): Şenay Kafkas, Ekrem Varoğlu, Dietrich Rebholz-Schuhmann and Bahar TaneriŞenay Kafkas, Ekrem Varoğlu, Dietrich Rebholz-Schuhmann and Bahar Taneri
Existing protein-protein interactions databases cover only a portion of the interactome and interaction information on protein isoforms is underrepresented. This leads to a lack of information on the functional similarity of protein isoforms and the effects of transcript diversity on the protein interaction networks. We present a comprehensive automated literature analysis that extracts interactions involving human protein isoforms linked to clusters of transcripts with high sequence similarity and deliver them in a database called TBIID for knowledge discovery. We measure the interaction variability of the isoforms from the clustered transcripts by analysing the distribution of their interaction partners in TBIID. Almost all clusters analyzed (99%) contain isoforms with unique partners indicating that isoforms are specialized towards forming unique interactions and thus achieving fun.. View More»
DOI:
10.4172/jpb.1000198