Journal of Proteomics & Bioinformatics

Journal of Proteomics & Bioinformatics
Open Access

ISSN: 0974-276X

+44 1223 790975

Denong Wang

Denong Wang
Tumor Glycomics Laboratory, Biosciences Division, SRI International,
333 Ravenswood Avenue, Menlo Park, CA 94025

  • Research Article
    N-glycan Cryptic Antigens as Active Immunological Targets in Prostate Cancer Patients
    Author(s): Denong WangDenong Wang

    Although tumor-associated abnormal glycosylation has been recognized for decades, information regarding host recognition of the evolving tumor glycome remains elusive. We report here a carbohydrate microarray analysis of a number of tumor-associated carbohydrates for their serum antibody reactivities and potential immunogenicity in humans. These are the precursors, cores and internal sequences of N-glycans. They are usually masked by other sugar moieties and belong to a class of glyco-antigens that are normally “cryptic”. However, viral expression of these carbohydrates may trigger host immune responses. For examples, HIV-1 and SARS-CoV display Man9 clusters and tri- or multi-antennary type II (Galβ1→4GlcNAc) chains (Tri/m-II), respectively; viral neutralizing antibodies often target these sugar moieties. We asked, therefore, whether prostate tumor expression of.. View More»
    DOI: 10.4172/jpb.1000218

    Abstract PDF

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