Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
+44 1223 790975
ISSN: 0974-276X
+44 1223 790975
Debmalya Barh
IIOAB, Nonakuri, Purba Medinipur, WB-721172
India
Research Article
In Silico Identification of Dual Ability of N. gonorrhoeae ddl for Developing Drug and Vaccine Against Pathogenic Neisseria and Other Human Pathogens
Author(s): Debmalya Barh, Amarendra Narayan Misra and Anil KumarDebmalya Barh, Amarendra Narayan Misra and Anil Kumar
The transmission and prevention of gonococcal infection is a global health problem and an effective drug or vaccine against the pathogen is yet to be developed. In our previous studies by analyzing metabolic pathways and membrane proteome of N. gonorrhoeae we found that four membrane associated targets could be better option in developing anti- gonorrhoeae drugs and vaccine. Here we showed that among these putative targets, D-alanine—D-alanine ligase (ddl) is the best candidate for development of both drug and vac- cine against N. gonorrhoeae and various other human bac- terial pathogens. Using in silico approaches, we developed the 3-D model of the enzyme and potential epitopes are also identified that may be helpful in peptide vaccine develop- ment against multiple pathogens including pathogenic Neis- seria . Epitopes require experimental validation.. View More»
DOI:
10.4172/jpb.1000125