Journal of Proteomics & Bioinformatics
Open Access

Daisuke Kubota

Publications

• Review Article
  Proteomic Approach to Gastrointestinal Stromal Tumor Identified Prognostic Biomarkers
  Author(s): Daisuke Kubota, Akihiko Yoshida, Kazutaka Kikuta, Tsuyoshi Saito, Yoshiyuki Suehara, Masahiro Gotoh, Akira Kawai and Tadashi Kondo Daisuke Kubota, Akihiko Yoshida, Kazutaka Kikuta, Tsuyoshi Saito, Yoshiyuki Suehara, Masahiro Gotoh, Akira Kawai and Tadashi Kondo
  
  Biomarker development is a major research theme in cancer proteomics. Cancer is a genetically and clinically diverse disease, and biomarkers for risk stratification therapy are urgently required. A considerable number of biomarker candidates have been discovered by proteomics, and over the last decade proteomics modalities have been developed to identify promising candidates. Validation studies involving hundreds of samples in independent cohorts is the next challenge to prove the clinical utility of any discovered biomarker candidates. Here, we review our efforts directed toward tissue biomarker development using a proteomics approach. With the aim of developing a prognostic biomarker for gastrointestinal stromal tumor (GIST), we examined the protein expression profiles of primary tumors from 17 GIST patients with different risks of recurrence and prognosis after surgery. Through a c.. View More»
  DOI: 10.4172/jpb.1000297

  Abstract PDF

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