Journal of Proteomics & Bioinformatics

Journal of Proteomics & Bioinformatics
Open Access

ISSN: 0974-276X

+44 1223 790975

Chunying Li

Chunying Li
Department of Biochemistry and Molecular Biology,
540 E. Canfield Avenue, 5312 Scott Hall, Detroit, Michigan 48201

  • Review Article
    Compartmentalized Regulation of CFTR Chloride Channel Function in Apical Epithelia
    Author(s): Chunying LiChunying Li

    The cystic fibrosis transmembrane conductance regulator (CFTR), a chloride channel that is located primarily at the apical plasma membrane of polarized epithelial cells, plays a crucial role in transepithelial fluid homeostasis. Tight regulation of CFTR function is critical, as either hypofunctioning or hyperfunctioning of CFTR activity may result in life-threatening disorders. Accumulating evidence has suggested that the regulation of CFTR channel function is highly compartmentalized, i.e., CFTR function is tightly fine-tuned in localized microdomains, in which CFTR-containing multiprotein complexes play a critical role. A growing number of proteins has been reported to interact directly or indirectly with CFTR, implying that CFTR is coupled functionally and/or physically to a wide variety of interacting partners including ion channels, receptors, transporters, scaffolding proteins, .. View More»
    DOI: 10.4172/jpb.1000283

    Abstract PDF

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